Hydroxypropyl Methylcellulose (HPMC) is a semisynthetic, inert polymer widely used in pharmaceutical formulations due to its versatility, safety, and functional properties. Derived from cellulose, HPMC serves as a critical excipient in oral, ophthalmic, and topical medications. Its water-solubility, thermal gelation, and film-forming abilities make it indispensable in drug delivery systems. In oral solid dosages, HPMC acts as a binder, ensuring tablet cohesion during compression, and as a controlled-release agent. When hydrated, it forms a hydrophilic matrix that gradually releases active ingredients, enhancing bioavailability and reducing dosing frequency. This property is vital for drugs requiring sustained therapeutic effects, such as antihypertensives or analgesics. HPMC is also a key component in film coatings for tablets and capsules. These coatings mask unpleasant tastes, improve swallowability, and protect drugs from moisture or light degradation. In ophthalmic solutions, HPMC’s mucoadhesive nature and lubricating properties make it ideal for artificial tears and eye drops. It prolongs contact time on the ocular surface, improving drug absorption and patient comfort. For topical applications, HPMC is used in gels and creams as a thickening agent, providing stable consistency and enhancing skin adhesion. Its non-irritating, non-allergenic profile ensures compatibility with sensitive tissues. Regulatory agencies like the USP and EP recognize HPMC as safe, with no significant toxicity or interactions reported. Its adaptability to various pH levels and compatibility with other excipients further solidify its role in modern pharma. As the industry shifts toward patient-centric formulations, HPMC remains a cornerstone excipient, balancing efficacy, safety, and cost-effectiveness. From extended-release tablets to sterile eye solutions, hydroxypropyl methylcellulose continues to enable innovative, reliable drug delivery across therapeutic categories.
(hydroxypropyl methylcellulose pharmaceutical use)
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